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KMID : 1155520170120030247
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Anesthesia and Pain Medicine
2017 Volume.12 No. 3 p.247 ~ p.250
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The effect-site concentration of remifentanil for blunting hemodynamic responses: comparative study in single-lumen endotracheal and double-lumen endobronchial intubation
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Park Sun-Kyung
Kim Hyun-Jung
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Abstract
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Background: This study undertook to compare the effect-site concentration of remifentanil for prevention of hemodynamic responses to endotracheal intubation, employing the single-lumen tracheal tube and the double-lumen bronchial tube during total intravenous anesthesia.
Methods:Based on the nature of the surgery, 38 patients undergoing general anesthesia were assigned either to the single- lumen tube group or the double-lumen tube group. Anesthesia was induced by a target controlled infusion of propofol, with an effect-site concentration of 4 μg/ml. Remifentanil was then administered to the first patient in each group, with an effect-site concentration of 3.5 ng/ml. Subsequent concentration of remifentanil was determined by hemodynamic responses of the previous patient to intubation, based on the up-and-down method.
Results:The effect-site concentrations of remifentanil for prevention of hemodynamic responses to endotracheal intubation in 50% of patients (EC50) were 2.8 ng/ml (95% CI, 2.0?3.7 ng/ml) in the single-lumen tube group, and 2.9 ng/ml (95% CI, 2.5?3.2 ng/ml) in the double-lumen tube group. No significant difference was observed between the two groups.
Conclusions:The effect-site concentration of remifentanil for prevention of hemodynamic responses to endotracheal intubation did not differ during total intravenous anesthesia, using either the single-lumen tracheal tube or the double-lumen bronchial tube.
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KEYWORD
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Endotracheal anesthesia, Intubation, Remifentanil
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